It’s the third time her cancer has come back, but Cindy Worrell was out there with the rest of her family and friends Saturday morning to cheer on the Pan-Mass Challenge bikers.

The Pan-Mass Challenge is a statewide bike ride spanning several different routes throughout Massachusetts, whose several thousand participants raise money for cancer research through the Dana-Farber Cancer Institute. This year there were 6,000 riders.

Worrell and her husband Geoff Worrell have been avid supporters of the Pan-Mass Challenge for the last 12 years.

“Most of these riders have come anywhere from 70 to 90 miles so far, so the least we can do is come out and cheer them on,” Geoff Worrell said. “For our family, it’s a really big deal, and … it’s become more of a personal thing.”

Cindy Worrell has non-Hodgkin lymphoma, which is a cancer that begins in the lymphocytes, and can spread to other areas of the body. She has been in remission twice since her diagnosis in 2004. She said she and her husband, who work in the mortgage business, like to encourage their friends and clients to come down to support the riders and the cause.

“We love to recruit anyone we can,” Worrell said.

Among their supporters was Dick Melloni, who runs the local Dick Melloni Youth Foundation. He said Cindy Worrell and his sisters, all of whom have had cancer, are his reason to support the ride.

“This is just a great cause, so why wouldn’t you support it?” Melloni asked. “[Cindy and Geoff] are two of the best people you are ever going to meet, two of the best people in town.”

Some supporters came wearing red, which is Worrell’s special color.

“Red is my fighting color,” Worrell said, plucking at the red scarf around her neck. “A few of our friends and their cousins are coming, and they’ve got theirs that they are bringing today, too.”

Geoff Worrell said the message he, his family, and their supporters hope to get across is that “everyone can make a difference.”

“Sometimes, people think that, in order to make a difference, you have to donate a lot of money, and stuff like that,” Worrell said. “But our take is that … we can just come out, and cheer people on. It encourages people, and it generates more support.”